The Initiative Of INIDA
Iatrogenic Neuroimmune Disease Association (INIDA) is a patient-led community effort focused on documenting clinical findings and advancing the understanding of novel drug-induced disorders. Through community gathered data we have created our first research document focused on Post SSRI Sexual Dysfunction PSSD, and we have a long-term goal of initiating research into other post-drug disorders as well.
Drug-Induced Disorders:
- Post SSRI Sexual Dysfunction (PSSD)
- Post Finasteride syndrome (PFS)
- Post Accutane syndrome (PAS)
- Post-Acute-Withdrawal Syndrome (PAWS)
- Neuroleptic induced deficit syndrome (NIDS)
- Fluoroquinolone antibiotic toxicity (“Floxies”)
- Autoimmune/inflammatory syndrome induced by adjuvants (ASIA Sydrome)
- Akathisia
- Tardive Dyskinesia
Drug-induced disorders, such as PSSD, PFS and PAS, are a novel class of medical conditions induced by medications. These conditions are defined by the initiation of symptoms following exposure to a pharmaceutical agent, the persistence of these symptoms even after discontinuation of the offending agent, and a distinct clinical presentation that sets them apart as unique medical entities. They're termed iatrogenic, meaning they are caused by medical interventions intended to treat a patient. While medications are developed and prescribed to treat patients, they can sometimes lead to unexpected adverse outcomes in a subset of genetically susceptible patients, igniting disease mechanisms that result in the development of new medical conditions such as autoimmune disease (Nugroho 2017), He & Sawalha 2020, Dedeoglu 2009).
"Although it is now becoming well-established that various environmental agents can cause epigenetic changes, one class of compounds that has been largely absent from most studies so far, is pharmaceutical drugs. Based on our rapidly-accumulating knowledge of gene/environment interactions, it stands to reason that drugs in current therapeutic practice would affect the epigenomic state of genes" (Csoka 2009).
Clinical trials mostly fail to detect drug-induced conditions like PSSD due to limited duration, underreporting and primary focus on short-term side effects, with the lack of long-term monitoring which is necessary for a condition like PSSD that develops after the drug has been discontinued and can persist indefinitely. Furthermore, the stigma surrounding medical harm may inhibit medical professionals and academics from approaching these conditions objectively. The acknowledgment of drug-induced disorders remains poor, despite increasing awareness among those affected, the literature remains sparse, with limited research dedicated to understanding the underlying mechanisms of these conditions. Patients require acknowledgment, along with research efforts aimed at identifying medical remedies.
With the formation of INIDA, we hope to spark greater interest among academic researchers and encourage professional involvement in studying these conditions. We aim to focus research on the emerging neuroimmunological component which our data is indicating to be involved in these disorders. immune-mediated neurological disease
Contact
We encourage researchers, medical professionals and journalists to contact us on email. For patients we ask that you join the Discord server using the discord link.